SN instructed patient that Eliquis is used to prevent serious blood clots from forming due to a certain irregular heartbeat ( atrial fibrillation ) or after hip/knee replacement surgery. With atrial fibrillation, part of the heart does not beat the way it should. This can lead to blood clots forming, which can travel to other parts of your body (such as the lungs or legs) or increase your risk for stroke. In the United States, apixaban is also approved to treat certain types of blood clots ( deep vein thrombosis - DVT, pulmonary embolus - PE ) and to prevent them from forming again. Eliquis is an anticoagulant that works by blocking certain clotting proteins in your blood. SN also instructed that Nausea, easy bruising, or minor bleeding ( such as nosebleed, bleeding from cuts ) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. This medication can cause serious bleeding if it affects your blood clotting proteins too much. Tell your doctor right away if you have any signs of serious bleeding, including: unusual pain / swelling / discomfort, unusual bruising, prolonged bleeding from cuts or gums, persistent / frequent nosebleeds, unusually heavy / prolonged menstrual flow, pink/dark urine, coughing up blood, vomit that is bloody or looks like coffee grounds, severe headache, dizziness / fainting, unusual or persistent tiredness / weakness, bloody / black / tarry stools, difficulty swallowing.