SN instructed patient / caregiver about Methylprednisolone ( Medrol ), it is a corticosteroid used to treat severe allergies, arthritis, asthma, and skin conditions. It may also be used to treat other conditions as determined by your doctor. Possible side effects, that may go away during treatment, include difficulty sleeping, mood changes, nervousness, increased appetite, or indigestion. If they continue or are bothersome, check with your doctor. Check with your doctor as soon as possible if you experience swelling of feet or legs unusual weight gain black, tarry stools vomiting material that looks like coffee grounds severe nausea or vomiting changes in menstrual periods headache muscle weakness or prolonged sore throat, cold or fever. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. DO NOT stop taking this medicine without checking with your doctor. Stopping this medicine suddenly may cause serious side effects. Keep all doctor and laboratory appointments while you are using this medicine. Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using this medicine. This medicine makes you more susceptible to illnesses, especially if you take it for an extended period of time. Prevent infection by avoiding contact with people who have colds or other infections. Report any injuries or signs of infection (fever, sore throat, pain during urination, or muscle aches) that occur during treatment and within 12 months after stopping this medicine.