Patient was instructed on new medication Sucralfate take this medication 1 hour before meals and at bedtime. Take sucralfate on an empty stomach, 2 hours after or 1 hour before meals. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sucralfate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.