SN educated patient/caregiver on medication Trelegy inhaler. This inhaler combines 3 medicines in 1 inhaler, an inhaled corticosteroid (ICS) medicine (fluticasone furoate), an anticholinergic medicine (umeclidinium), and a long-acting beta2-adrenergic agonist (LABA) medicine (vilanterol). ICS medicines such as fluticasone furoate help to decrease inflammation in the lungs. Anticholinergic medicines such as umeclidinium and LABA medicines such as vilanterol help the muscles around the airways in your lungs stay relaxed to prevent symptoms such as wheezing, cough, chest tightness, and shortness of breath. Common side effects include: thrush in your mouth and throat, (rinse your mouth with water without swallowing after use to help prevent this.) bronchitis, PNA, upper respiratory infection, painful urination, throat/mouth pain, cough, hoarseness.