Instructed what can you do to manage shortness of breath (SOB) make lifestyle changes take your medications as prescribed there are some medications that can help shortness of breath. You may need oxygen if your oxygen level is low. Your health care team will test your levels if you are having shortness of breath. Pace yourself break your activities down into smaller steps. Plan your activities so that you have time to do them slowly and comfortably. Keep things that you use often close by and within easy reach.