Patient instructed on new medication Abilify. Abilify is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar I disorder (manic depression). It is also used together with other medicines to treat major depressive disorder in adults. May be taken with or without food, take at the same time daily. Do not stop abruptly or change dosage without consulting prescriber. Notify prescriber if unusual or bothersome side effects occur.