SN instructed patient that Xifaxan is used for cessation of traveler's diarrhea and the reduction in risk of overt hepatic encephalopathy. Side effects are dizziness and peripheral edema. SN instructed patient to take rifaximin as directed and to complete therapy, even if feeling better. Caution patient to stop taking rifaximin if diarrhea symptoms get worse, persist more than 24–48 hr or are accompanied by fever or blood in the stool. Consult health care professional if these occur. Advise patient not to treat diarrhea without consulting health care professional. May occur up to several weeks after discontinuation of medication. Caution patient to avoid driving and other activities requiring alertness until response to medication is known.