Instructed patient in new medication side effects; the most common side effect is hot flashes (50% of patients) and facial flushing. Alcohol may worsen this reaction, and so it should be cautiously consumed. Other common side effects of the combination are diarrhea, constipation and overall pain including pain in the back, hips and stomach. Less common side effects are breast enlargement and breast pain, which may be due to the bicalutamide alone.