SN instructed patient and caregiver on SIMVASTATIN. Simvastatin is a cholesterol-lowering medicine. It inhibits the production of cholesterol by the liver. High blood cholesterol is first treated with exercise, weight loss, and a diet low in cholesterol and saturated fats. When these measures fail, cholesterol-lowering medications such as Simvastatin can be added. Simvastatin is generally well-tolerated and side effects are rare. Minor side effects of Simvastatin include constipation, diarrhea, fatigue, gas, heartburn, and headache. Major side effects of Simvastatin include abdominal pain or cramps, blurred vision, dizziness, easy bruising or bleeding, itching, muscle pain or cramps, rash, and yellowing of the skin or eyes.