Take the Actonel tablet first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. Take each dose with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking a Actonel tablet. For at least the first 30 minutes after taking an Actonel tablet, do not lie down or recline; do not eat or drink anything other than plain water; and do not take any other medicines including vitamins, calcium, or antacids.