SN instructed patient about oxycodone/ acetaminophen ,non-serious adverse reactions include lightheadedness, dizziness, drowsiness or sedation, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in no ambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Other adverse reactions include euphoria, dysphoria, constipation, and pruritus. Serious SE/AR include respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, and shock .